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Phosphorus (PO₄³⁻)

Normal 3.0–4.5 mg/dL
Why it matters

Energy (ATP) and cell membranes. See-saws with calcium.

LOW — Hypophosphatemia (< 3.0)
Causes
REFEEDING syndrome — starting nutrition on the malnourishedAlcohol use disorderDKA treatmentAntacid binding
Signs
Muscle weakness — including respiratory musclesConfusionDifficulty weaning from the vent
Nursing actions
  • Starting feeds on a malnourished/alcohol-use patient: watch phos daily for the first days
  • Watch work of breathing at severe lows
  • Replace per orders
HIGH — Hyperphosphatemia (> 4.5)
Causes
Renal failureTumor lysis syndromeRhabdomyolysis
Signs
Mostly shows as LOW-calcium signs (tingling, spasm)Itching in renal patientsCalcium-phosphate deposits long-term
Nursing actions
  • Phosphate binders WITH meals (they bind food phosphorus — timing is the whole point)
  • Renal diet teaching
  • Watch the calcium
Source: Ignatavicius, Medical-Surgical Nursing, 10th ed.Reference only — verify against your facility's policy.

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