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Corticosteroids (systemic)

-sone, -solone
How it works

Mimic cortisol — broad anti-inflammatory and immunosuppressive shutdown of the immune response.

You'll see
prednisonemethylprednisolonedexamethasonehydrocortisone
Used for
COPD/asthma exacerbationsAutoimmune flaresCerebral edema (dex)Adrenal insufficiency
Side effects
Hyperglycemia (check sugars even in non-diabetics)Infection risk with masked feverGI bleedingInsomnia, mood swingsLong-term: osteoporosis, skin thinning, adrenal suppression
Monitor
  • Blood glucose — steroid hyperglycemia is near-universal at real doses
  • Infection signs WITHOUT relying on fever
  • Give with food; watch for GI bleed with concurrent NSAIDs
  • Long-term users must never stop abruptly — adrenal crisis
🎓 Patient teaching

Take with food, in the morning (mimics cortisol rhythm, helps sleep). Never stop suddenly after long-term use — taper only. Report black stools. Expect appetite and mood changes.

Source: Lehne's Pharmacology for Nursing Care, 11th ed.Reference only — verify against your facility's policy.

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