NSAIDs
(ibuprofen, -oxicam, ketorolac)How it works
Block COX enzymes → less prostaglandin → less pain, fever, inflammation. Same block hits stomach lining and kidney blood flow.
You'll see
Used for
Side effects
Monitor
- Creatinine and the trifecta: NSAID + ACE/ARB + diuretic = AKI recipe
- Ketorolac: 5-day maximum, renally cautious — flag day 6
- Bleeding risk stacked with anticoagulants/steroids
- Often the hidden culprit behind rising creatinine — check home OTC use
🎓 Patient teaching
Take with food. Don't stack with other OTC NSAIDs (many cold medicines contain them). Kidney, heart, and ulcer patients: ask before using at all.
Source: Lehne's Pharmacology for Nursing Care, 11th ed.Reference only — verify against your facility's policy.
