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Insulins

(by onset: rapid → long)
How it works

Moves glucose into cells. The onset/peak/duration ladder is the whole game: rapid ~15 min onset; regular ~30 min; NPH peaks 4–12 h; glargine has no real peak.

You'll see
lispro/aspart (rapid)regular (short)NPH (intermediate)glargine/detemir (long)
Used for
Type 1 (always)Type 2 when orals aren't enoughHyperkalemia (with D50)DKA (regular, IV)
Side effects
HYPOGLYCEMIA — the one that killsWeight gainLipohypertrophy at overused sites
Monitor
  • Match the food to the peak: rapid insulin given, tray delayed = hypoglycemia incoming
  • NPO patient with insulin ordered? Clarify BEFORE giving
  • Only REGULAR insulin goes IV
  • Draw clear (regular) before cloudy (NPH) when mixing
  • High-alert: two-nurse check per policy
🎓 Patient teaching

Rotate sites within a region. Know YOUR insulin's peak — that's when lows happen. Carry fast sugar. Never skip insulin because you're not eating without calling first.

Source: Lehne's Pharmacology for Nursing Care, 11th ed.; ADA Standards of CareReference only — verify against your facility's policy.
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